Traumatic Brain Injury
The Traumatic Brain Injury (TBI) research program in the Department of Epidemiology focuses on improving clinical research methods and identifying effective treatments for individuals with TBI.
Collaborations with the IMPACT investigators include:
- Examining the epidemiology and short- and long-term outcomes of TBI
- Strengthening experimental study design in TBI research
- Evaluating the effects of outcome misclassification in TBI clinical trials and developing methods to reduce Glasgow Outcome misclassification
Long-standing collaborations with Oslo University Hospital and University of Oslo focus on:
- Transitional care, service utilization, and the cost-effectiveness of rehabilitation for individuals with TBI
- Developing effective rehabilitation interventions for patients with TBI
- Assessing long-term outcomes following moderate and severe TBI
Ongoing projects
This work aims at understanding the impact of Glasgow Outcome misclassification through sensitivity analysis in order to develop, validate and implement an online outcome data collection tool that minimizes outcome misclassification in TBI clinical trials. This is a collaborative research effort with IMPACT investigators (International Mission for Prognosis and Analysis of Clinical Trials in TBI), and the project was funded by NIH and sponsored by BHR Pharma in a later phase.
Two rehabilitation intervention studies were funded recently by the Norwegian Health Council. One intervention was designed to target at the community level, and the other was designed with combined cognitive and vocational intervention components for patients with TBI. This is collaborative research with the Department of Physical Medicine and Rehabilitation, Oslo University Hospital and Research Center and Rehabilitation Models and Services (CHARM) at Oslo University, Norway. I am a guest professor for the program of CHARM and PI via a subcontract.
Studying long-term outcomes following moderate and severe TBI: A couple of activities are ongoing to (1) understand the trajectories of long-term functional outcomes and (2) multi-dimensional outcomes following moderate and severe TBI. Again, this is a collaborative research effort with CHARM.